Publications
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2022
Virk R, Buddenbaum N, Al-Shaer A, Armstrong M, Manke J, Reisdorph N, Sergin S, Fenton JI, Wallace ED, Ehrmann BM, Lovins HB, Gowdy KM, Smith MR, Smith GJ, Kelada SNP, Shaikh SR. Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks. J Lipid Res. 2022 Oct;63(10):100267. doi: 10.1016/j.jlr.2022.100267. Epub 2022 Aug 24.PMID: 36028048 Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T-Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1;208(7):1525-1533. doi: 10.4049/jimmunol.2100994. Epub 2022 Mar 14.PMID: 35288471 Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 Feb;66(2):e1-e14. doi: 10.1165/rcmb.2021-0531ST.PMID: 35103557. Green WD, Al-Shaer AE, Shi Q, Gowdy KM, MacIver NJ, Milner JJ, Beck MA, Shaikh SR. An Metabolic and functional impairment of CD8+ T-cells from the lungs of influenza-infected obese mice. J Leukoc Biol. 2022 Jan;111(1):147-159. doi: 10.1002/JLB.4A0120-075RR. Epub 2021 Apr 13.PMID: 33847405 2021 Mahuire RL, House JS, Lloyd DT, Skinner HG, Allen TK, Raffi AM, Skaar DA, Park SS, McCullough LE, Kollins SH, Bilbo SD, Collier DN, Murphy SK, Fuemmeler BF, Gowdy KM, Hoyo C. Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort. igPediatr Obes. 2021 Jul;16(7):e12763. doi: 10.1111/ijpo.12763. Epub 2020 Dec 30. PMID: 33381912. Mattox TA, Psaltis C, Weihbrecht K, Robidoux J, Kilburg-Basnyat B, Murphy MP, Gowdy KM, Anderson EJ. Prohibition-1 is a Dynamically Regulated Blood Protein with Cardioprotective Effects in Sepsis. J Am Heart Assoc. 2021 Jul 20;10(14):e019877. doi: 10.1161/JAHA.120.019877. Epub 2021 Jul 3.PMID: 34219469 Reece SW, Varikuti S, Kilburg-Basnyat B, Dunigan-Russell K, Hodge MX, Luo B, Madenspacher JH, Thomas SY, Tokarz DA, Tighe RM, Cook DN, Fessler MB, Gowdy KM. Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma. Am J Respir Cell Mol Biol. 2021 Jun;64(6):698-708. doi: 10.1165/rcmb.2020-0007OC.PMID: 33647226 2020 Pal A, Gowdy KM, Oestreich KJ, Beck M, Shaikh SR. Cell Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection. Front Immunol. 2020 Aug 11;11:1997. doi: 10.3389/fimmu.2020.01997. PMID: 32983141; PMCID: PMC7438933. Madenspacher JH, Morrell ED, Gowdy KM, McDonald JG, Thompson BM, Muse G, Martinez J, Thomas S, Mikacenic C, Nick JA, Abraham E, Garantziotis S, Stapleton RD, Meacham JM, Thomassen MJ, Janssen WJ, Cook DN, Wurfel MM, Fessler MB. Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. JCI Insight. 2020 Jun 4;5(11):e137189. doi: 10.1172/jci.insight.137189. PMID: 32343675; PMCID: PMC7308063. Iñigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE. Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab. 2020 Apr;34:1-15. doi: 10.1016/j.molmet.2019.12.010. Epub 2019 Dec 23. PMID: 32180550; PMCID: PMC6994285. Hussain S, Johnson CG, Sciurba J, Meng X, Stober VP, Liu C, Cyphert-Daly JM, Bulek K, Qian W, Solis A, Sakamachi Y, Trempus CS, Aloor JJ, Gowdy KM, Foster WM, Hollingsworth JW, Tighe RM, Li X, Fessler MB, Garantziotis S. TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. Elife. 2020 Jan 28;9:e50458. doi: 10.7554/eLife.50458. PMID: 31989925; PMCID: PMC7032926. Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020 Jan 2;130(1):157-170. doi: 10.1172/JCI127144. PMID: 31550239; PMCID: PMC6934223. 2019 McDaniel DK, Ringel-Scaia VM, Morrison HA, Coutermarsh-Ott S, Council-Troche M, Angle JW, Perry JB, Davis G, Leng W, Minarchick V, Yang Y, Chen B, Reece SW, Brown DA, Cecere TE, Brown JM, Gowdy KM, Hochella MF Jr, Allen IC. Pulmonary Exposure to Magneli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function. Front Immunol. 2019 Nov 28;10:2714. doi: 10.3389/fimmu.2019.02714. PMID: 31849940; PMCID: PMC6892980. Martinu T, McManigle WC, Kelly FL, Nelson ME, Sun J, Zhang HL, Kolls JK, Gowdy KM, Palmer SM. IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease. Transplantation. 2019 Nov;103(11):2264-2274. doi: 10.1097/TP.0000000000002837. PMID: 31658231; PMCID: PMC7550218. Hodge MX, Reece SW, Madenspacher JH, Gowdy KM. In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure. J Vis Exp. 2019 Oct 22;(152):10.3791/60109. doi: 10.3791/60109. PMID: 31710036; PMCID: PMC7507829. Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH. Correction: Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J. 2019 Sep 13;476(17):2519. doi: 10.1042/BCJ-2019-0182_COR. Erratum for: Biochem J. 2019 May 31;476(10):1521-1537. PMID: 31519859. McPeek M, Malur A, Tokarz DA, Lertpiriyapong K, Gowdy KM, Murray G, Wingard CJ, Fessler MB, Barna BP, Thomassen MJ. Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation. Am J Respir Cell Mol Biol. 2019 Sep;61(3):332-340. doi: 10.1165/rcmb.2018-0365OC. PMID: 30848658; PMCID: PMC6839925. Birukova A, Cyphert-Daly J, Cumming RI, Yu YR, Gowdy KM, Que LG, Tighe RM. Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses. Toxicol Sci. 2019 Jun 1;169(2):499-510. doi: 10.1093/toxsci/kfz056. PMID: 30825310; PMCID: PMC6542336. Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH. Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J. 2019 May 31;476(10):1521-1537. doi: 10.1042/BCJ20190182. Erratum in: Biochem J. 2019 Sep 13;476(17):2519. PMID: 31092703; PMCID: PMC7071349. Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK, Hoyo C. Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an association study. Epigenetics. 2019 Apr;14(4):325-340. doi: 10.1080/15592294.2019.1581594. Epub 2019 Mar 26. PMID: 30773972; PMCID: PMC6557549. McGee CE, Sample CJ, Kilburg-Basnyat B, Gabor KA, Fessler MB, Gowdy KM. Influenza-Mediated Lung Infection Models. Methods Mol Biol. 2019;1960:191-205. doi: 10.1007/978-1-4939-9167-9_17. PMID: 30798533; PMCID: PMC6675590. Aloor JJ, Azzam KM, Guardiola JJ, Gowdy KM, Madenspacher JH, Gabor KA, Mueller GA, Lin WC, Lowe JM, Gruzdev A, Henderson MW, Draper DW, Merrick BA, Fessler MB. Leucine-rich repeats and calponin homology containing 4 (Lrch4) regulates the innate immune response. J Biol Chem. 2019 Feb 8;294(6):1997-2008. doi: 10.1074/jbc.RA118.004300. Epub 2018 Dec 6. PMID: 30523158; PMCID: PMC6369294. 2018 Espenschied ST, Tighe RM, Gowdy KM. Flow Cytometry for the Immunotoxicologist. Methods Mol Biol. 2018;1803:183-197. doi: 10.1007/978-1-4939-8549-4_12. PMID: 29882140. Tighe RM, Birukova A, Yaeger MJ, Reece SW, Gowdy KM. Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation. Am J Respir Cell Mol Biol. 2018 Aug;59(2):257-266. doi: 10.1165/rcmb.2017-0357OC. PMID: 29481287; PMCID: PMC6096344. Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, Armstrong ML, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM. Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation. Toxicol Sci. 2018 Jun 1;163(2):466-477. doi: 10.1093/toxsci/kfy040. PMID: 29471542; PMCID: PMC5974791. |
Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN. MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens. Mucosal Immunol. 2018 May;11(3):796-810. doi: 10.1038/mi.2017.84. Epub 2017 Oct 25. PMID: 29067999; PMCID: PMC5918466.
Snow SJ, Cheng WY, Henriquez A, Hodge M, Bass V, Nelson GM, Carswell G, Richards JE, Schladweiler MC, Ledbetter AD, Chorley B, Gowdy KM, Tong H, Kodavanti UP. Ozone-Induced Vascular Contractility and Pulmonary Injury Are Differentially Impacted by Diets Enriched With Coconut, Fish Oil, and Olive Oil. Toxicol Sci. 2018 May 1;163(1):57-69. doi: 10.1093/toxsci/kfy003. PMID: 29329427; PMCID: PMC6659020. McGee Hargrove M, Snow SJ, Luebke RW, Wood CE, Krug JD, Krantz QT, King C, Copeland CB, McCullough SD, Gowdy KM, Kodavanti UP, Gilmour MI, Gavett SH. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. Environ Sci Technol. 2018 Mar 6;52(5):3062-3070. doi: 10.1021/acs.est.7b06534. Epub 2018 Feb 14. PMID: 29384667; PMCID: PMC6233996.Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.Maguire RL, House JS, Lloyd DT, Skinner HG, Allen TK, Raffi AM, Skaar DA, Park SS, McCullough LE, Kollins SH, Bilbo SD, Collier DN, Murphy SK, Fuemmeler BF, Gowdy KM, Hoyo C.Pediatr Obes. 2021 Jul;16(7):e12763. doi: 10.1111/ijpo.12763. Epub 2020 Dec 30.PMID: 33381912 2017 Henderson MW, Madenspacher JH, Whitehead GS, Thomas SY, Aloor JJ, Gowdy KM, Fessler MB. Effect of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice. Environ Health Perspect. 2017 Sep 28;125(9):097024. doi: 10.1289/EHP1878. PMID: 28960179; PMCID: PMC5915208. Azzam KM, Madenspacher JH, Cain DW, Lai L, Gowdy KM, Rai P, Janardhan K, Clayton N, Cunningham W, Jensen H, Patel PS, Kearney JF, Taylor GA, Fessler MB. lrgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces. JCI Insight. 2017 Aug 17;2(16):e91914. doi: 10.1172/jci.insight.91914. PMID: 28814662; PMCID: PMC5621910. Kosaraju R, Guesdon W, Crouch MJ, Teague HL, Sullivan EM, Karlsson EA, Schultz-Cherry S, Gowdy KM, Bridges LC, Reese LR, Neufer PD, Armstrong M, Reisdorph N, Milner JJ, Beck M, Shaikh SR. B Cell Activity is Impaired in Human and Mouse Obesity and is Responsive to an Essential Fatty Acid upon Murine Influenza Infection. J Immunol. 2017 Jun 15;198(12):4738-4752. doi: 10.4049/jimmunol.1601031. Epub 2017 May 12. PMID: 28500069; PMCID: PMC5482422. 2016 Speen AM, Kim HH, Bauer RN, Meyer M, Gowdy KM, Fessler MB, Duncan KE, Liu W, Porter NA, Jaspers I. Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID_PROTEIN ADDUCTS. J Biol Chem. 2016 Nov 25;291(48):25192-25206. doi: 10.1074/jbc.M116.732362. Epub 2016 Oct 4. PMID: 27703007; PMCID: PMC5122785. Shaikh SR, Fessler MB, Gowdy KM. Role for phospholipid acyl chains and cholesterol in pulmonαy infections and inflammation. J Leukoc Biol. 2016 Nov;100(5):985-997. doi: 10.1189/jlb.4VMR0316-103R. Epub 2016 Jun 10. PMID: 27286794; PMCID: PMC5069085. Whelan J, Gowdy KM, Shaikh SR. N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections. Eur J Pharmacol. 2016 Aug 15;785:10-17. doi: 10.1016/j.ejphar.2015.03.100. Epub 2015 May 27. PMID: 26022530; PMCID: PMC4662641. Thompson LC, Holland NA, Snyder RJ, Luo B, Becak DP, Odom JT, Harrison BS, Brown JM, Gowdy KM, Wingard CJ. Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L142-54. 2015 Whelan J, Gowdy KM, Shaikh SR. N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections. Eur J Pharmacol. 2015 May 27. pii: S0014-2999(15)00465-3. Gowdy KM, Madenspacher JH, Azzam KM, Gabor KA, Janardhan KS, Aloor JJ, Fessler MB. Key role in scavenger receptor B-I in the integrative physiology of host defense during bacterial pneumonia. Mucosal Immunol. 2015 May;8(3):559-71. Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM. Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection. Transpl Immunol. 2015 Jan;32(1):51-60. #229a64 Hsia BJ, Whitehead GS, Thomas SY, Nakano K, Gowdy KM, Aloor JJ, Nakano H, Cook DN. Trif-dependent induction of Th17 immunity by lung dendritic cells. Mucosal Immunol. 2015 Jan;8(1):186-97. 2014 Martinu T, Gowdy KM, Nugent JL, Sun J, Kinnier CV, Nelson ME, Lyes MA, Kelly FL, Foster WM, Gunn MD, Palmer SM. Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations. Am J Respir Cell Mol Biol. 2014 Dec;51(6):810-21. 2013 Gowdy KM, Fessler MB. Emerging roles for cholesterol and lipoproteins in lung disease. Pulm Pharmacol Ther. 2013 Aug;26(4):430-7. Jaramillo R, Cohn RD, Crockett PW, Gowdy KM, Zeldin DC, Fessler MB. Reply: To PMID 22921873. J Allergy Clin Immunol. 2013 Jun;131(6):1715-6. Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB. p53 Integrates host defense and cell fate during bacterial pneumonia. J Exp Med. 2013 May 6;210(5):891-904. 2012 Madenspacher JH, Azzam KM, Gong W, Gowdy KM, Vitek MP, Laskowitz DT, Remaley AT, Wang JM, Fessler MB. Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. J Biol Chem. 2012 Dec 21;287(52):43730-40. Zhu X, Westcott MM, Bi X, Liu M, Gowdy KM, Seo J, Cao Q, Gebre AK, Fessler MB, Hiltbold EM, Parks JS. Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. Circ Res. 2012 Nov 9;111(11):1398-409. Draper DW, Gowdy KM, Madenspacher JH, Wilson RH, Whitehead GS, Nakano H, Pandiri AR, Foley JF, Remaley AT, Cook DN, Fessler MB. ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity. J Immunol. 2012 Jun 1;188(11):5327-36. Gowdy KM, Cardona DM, Nugent JL, Giamberardino C, Thomas JM, Mukherjee S, Martinu T, Foster WM, Plevy SE, Pastva AM, Wright JR, Palmer SM. Novel role for surfactant protein A in gastrointestinal graft-versus-hot disease. J Immunol. 2012 May 15;188(10):4897-905. Mukherjee S, Giamberardino C, Thomas JM, Gowdy K, Pastva AM, Wright JR. Surfactant protein A modulates induction of regulatory T cells via TGF-B. J Immunol. 2012 May 1;188(9):4376-84. Gowdy KM, Nugent JL, Martinu T, Potts E, Snyder LD, Foster WM, Palmer SM. Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. Am J Respir Cell Mol Biol. 2012 Feb;46(2):249-56. 2011 Martinu T, Kinnier CV, Gowdy KM, Kelly FL, Snyder LD, Jiang D, Foster WM, Garantziotis S, Belperio JA, Noble PW, Palmer SM. Innate immune activation potentiates alloimmune lung disease independent of chemokind (C-X-C motif) receptor 3. J Heart Lung Transplant. 2011 Jun;30(6):717-25. Kinnier CV, Martinu T, Gowdy KM, Nugent JL, Kelly FL, Palmer SM. Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant. Transpl Immunol. 2011 Jan 15;24(2):83-93. 2010 Gowdy KM, Krantz QT, King C, Boykin E, Jaspers I, Linak WP, Gilmour MI. Role of oxidative stress on diesel-enhanced influenza infection in mice. Part Fibre Toxicol. 2010 Nov 22;7:34. 2008 Gowdy K, Krantz QT, Daniels M, Linak WP, Jaspers I, Gilmour MI. Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust. Toxicol Appl Pharmacol. 2008 Jun 15;229(3):310-9. 2007 Ciencewicki J, Gowdy K, Krantz QT, Linak WP, Brighton L, Gilmour MI, Jaspers I. Diesel exhaust enhanced susceptibility to influenza infection is associated with decreased surfactant protein expression. Inhal Toxicol. 2007 Nov;19(14):1121-33. |