Publications

2025

Dietary Eicosapentaenoic Acid Improves Ozone-Induced Pulmonary Inflammation in C57BL/6 Mice.
Lovins HB, Mehta A, Leuenberger LA, Yaeger MJ, Schott E, Hutton G, Manke J, Armstrong M, Reisdorph N, Tighe RM, Cochran SJ, Shaikh SR, Gowdy KM.
J Nutr. 2025 Feb;155(2):465-475. doi: 10.1016/j.tjnut.2024.11.006. Epub 2024 Nov 12. PMID: 39536972

Omega-3 Fatty Acids and Chronic Lung Diseases: A Narrative Review of Impacts from Womb to Tomb.
Yaeger MJ, Leuenberger L, Shaikh SR, Gowdy KM.
J Nutr. 2025 Feb;155(2):453-464. doi: 10.1016/j.tjnut.2024.10.028. Epub 2024 Oct 16. PMID: 39424068 Review.

2024

Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.
Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S, Grant RA, Abdala-Valencia H, Mylvaganam RJ, Ludwig A, Miller J, Cumming RI, Tighe RM, Gowdy KM, Kalhan R, Jain M, Bharat A, Kurihara C, San Jose Estepar R, San Jose Estepar R, Washko GR, Shilatifard A, Sznajder JI, Ridge KM, Budinger GRS, Braun R, Misharin AV, Sala MA.
Nat Immunol. 2024 Nov;25(11):2097-2109. doi: 10.1038/s41590-024-01975-x. Epub 2024 Oct 4. PMID: 39367123 

How Membrane Phospholipids Containing Long-Chain Polyunsaturated Fatty Acids and Their Oxidation Products Orchestrate Lipid Raft Dynamics to Control Inflammation.
Virk R, Cook K, Cavazos A, Wassall SR, Gowdy KM, Shaikh SR.
J Nutr. 2024 Sep;154(9):2862-2870. doi: 10.1016/j.tjnut.2024.07.015. Epub 2024 Jul 25. PMID: 39025329

Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction.
Gowdy KM, Shannahan J.
Toxicol Sci. 2024 May 28;199(2):161-162. doi: 10.1093/toxsci/kfae036.
PMID: 38804167.

Docosahexaenoic Acid Controls Pulmonary Macrophage Lipid Raft Size and Inflammation.
Pennington ER, Virk R, Bridges MD, Bathon BE, Beatty N, Gray RS, Kelley P, Wassall SR, Manke J, Armstrong M, Reisdorph N, Vanduinen R, Fenton JI, Gowdy KM, Shaikh SR.
J Nutr. 2024 Jun;154(6):1945-1958. doi: 10.1016/j.tjnut.2024.04.006. Epub 2024 Apr 4. PMID: 38582385.

Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats.
Cochran SJ, Dunigan-Russell K, Hutton GM, Nguyen H, Schladweiler MC, Jones DP, Williams WC, Fisher AA, Gilmour MI, Dye JA, Smith MR, Miller CN, Gowdy KM.
Toxicol Sci. 2024 May 28;199(2):332-348. doi: 10.1093/toxsci/kfae040.
PMID: 38544285 

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.
Guttenberg MA, Vose AT, Birukova A, Lewars K, Cumming RI, Albright MC, Mark JI, Salazar CJ, Swaminathan S, Yu Z, Sokolenko YV, Bunyan E, Yaeger MJ, Fessler MB, Que LG, Gowdy KM, Misharin AV, Tighe RM.
Am J Respir Cell Mol Biol. 2024 Jun;70(6):493-506. doi: 10.1165/rcmb.2023-0390OC. PMID: 38386777 

Estrogen contributes to sex differences in M2a macrophages during multi-walled carbon nanotube-induced respiratory inflammation.
Ray JL, Postma B, Kendall RL, Ngo MD, Foo CX, Saunders B, Ronacher K, Gowdy KM, Holian A.
FASEB J. 2024 Jan;38(1):e23350. doi: 10.1096/fj.202301571RR.
PMID: 38071600

Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury.
Yaeger MJ, Shaikh SR, Gowdy KM.
Am J Respir Cell Mol Biol. 2024 Jan;70(1):3-4. doi: 10.1165/rcmb.2023-0312ED.
PMID: 37747355 

2023

Sterols and immune mechanisms in asthma.
Rodney D Britt Jr, Ned Porter, Mitchell H Grayson, Kymberly M Gowdy, Megan Ballinger, Kara Wada, Hye-Young Kim, Mireia Guerau-de-Arellano. 
J Allergy Clin Immunol. doi: 10.1016/j.jaci.2022.09.025. PMCID: PMC10151016

Eos Promotes TH2 Differentiation by Interacting with and Propagating the Activity of STAT5. 
Jasmine A Tuazon, Kaitlin A Read, Bharath K Sreekumar, Jack E Roettger, Michael J Yaeger, Sanjay Varikuti, Srijana Pokhrel, Devin M Jones, Robert T Warren, Michael D Powell, Mustafa N Rasheed, Elizabeth G Duncan, Lauren M Childs, Kymberly M Gowdy, Kenneth J Oestreich.
 J Immunol. doi: 10.4049/jimmunol.2200861. PMID: 37314436

Aspirin modulates production of pro-inflammatory and pro-resolvin mediators in endothelial cells. 
Kara M Rood, Niharika Patel, Ivana M DeVengencie, John P Quinn, Kymberly M Gowdy, Maged M Costantine, Douglas A Kniss. 
PLoS One. doi: 10.1371/journal.pone.0283163. eCollection 2023. PMCID: PMC10128936

Resolution of inflammation in xenobiotic-induced mucosal injury and chronic disease. 
Kymberly M Gowdy, Debra L Laskin.
Toxicol Appl Pharmacol. doi: 10.1016/j.taap.2023.116455. PMID: 36907382

OxPAPC stabilizes liquid-ordered domains in biomimetic membranes. 
Andres T Cavazos, Edward Ross Pennington, Sahil Dadoo, Kymberly M Gowdy, Stephen R Wassall, Saame Raza Shaikh. 
Biophys J. doi: 10.1016/j.bpj.2023.02.024. PMCID: PMC10111260

The prohibition complex regulates macrophage fatty acid composition, plasma membrane packing, and lipid raft-mediated inflammatory signaling. 
Christine E Psaltis Matthews, Lynn A Fussner, Michael Yaeger, Jim J Aloor, Sky W Reece, Brita J Kilburg-Basnyat, Sanjay Varikuti, Bin Luo, Morgan Inks, Selin Sergin, Cameron A Schmidt, P Darrell Neufer, Edward Ross Pennington, Kelsey H Fisher-Wellman, Saiful M Chowdhury, Michael B Fessler, Jenifer I Fenton, Ethan J Anderson, Saame Raza Shaikh, Kymberly M Gowdy. 
Prostaglandins Leukot Essent Fatty Acids. doi: 10.1016/j.plefa.2023.102540. PMCID: PMC9992117

Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation. 
Katelyn Dunigan-Russell, Michael J Yaeger, Myles X Hodge, Brita Kilburg-Basnyat, Sky W Reece, Anastasiya Birukova, Marissa A Guttenberg, Caymen Novak, Sangwoon Chung, Brandie Michelle Ehrmann, E Diane Wallace, Debra Tokarz, Nairrita Majumder, Li Xia, John W Christman, Jonathan Shannahan, Megan N Ballinger, Salik Hussain, Saame Raza Shaikh, Robert M Tighe, Kymberly M Gowdy. 
Toxicol Appl Pharmacol. doi: 10.1016/j.taap.2023.11638. PMCID: PMC9983330

Air Pollution and respiratory infections: the past, present, and future.
Alexys Monoson, Evangeline Schott, Kerry Ard, Brita Kilburg-Basnyat, Robert M Tighe, Sonal Pannu, Kymberly M Gowdy.
Toxicol Sci. doi: 10.1093/toxsci/kfad003. PMCID: PMC1025881

Ozone impairs endogenous compensatory responses in allergic asthma.
Kevin Ho, David Weimar, Gina Torres-Matias, Hyunwook Lee, Saaleha Shamsi, Emily Shalosky, Michael Yaeger, Hannah Hartzler-Lovins, Katelyn Dunigan-Russell, Daria Jelic, Caymen M Novak, Kymberly M Gowdy, Joshua A Englert, Megan N Ballinger.
Toxicol Appl Pharmacol. doi:m10.1016/j.taap.2022.116341. PMCID: PMC9840700

2022

Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks.
Virk R, Buddenbaum N, Al-Shaer A, Armstrong M, Manke J, Reisdorph N, Sergin S, Fenton JI, Wallace ED, Ehrmann BM, Lovins HB, Gowdy KM, Smith MR, Smith GJ, Kelada SNP, Shaikh SR.
 J Lipid Res. doi: 10.1016/j.jlr.2022.100267. PMID: 36028048

PRMT5 in T-Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M.
J Immunol. doi: 10.4049/jimmunol.2100994. PMID: 35288471

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. 
Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2021-0531ST. PMID: 35103557.

Metabolic and functional impairment of CD8+ T-cells from the lungs of influenza-infected obese mice.
Green WD, Al-Shaer AE, Shi Q, Gowdy KM, MacIver NJ, Milner JJ, Beck MA, Shaikh SR.
​ J Leukoc Biol. doi: 10.1002/JLB.4A0120-075RR. PMID: 33847405 

2021 

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.
Mahuire RL, House JS, Lloyd DT, Skinner HG, Allen TK, Raffi AM, Skaar DA, Park SS, McCullough LE, Kollins SH, Bilbo SD, Collier DN, Murphy SK, Fuemmeler BF, Gowdy KM, Hoyo C.
igPediatr Obes. doi: 10.1111/ijpo.12763. PMID: 33381912.

Prohibition-1 is a Dynamically Regulated Blood Protein with Cardioprotective Effects in Sepsis.
Mattox TA, Psaltis C, Weihbrecht K, Robidoux J, Kilburg-Basnyat B, Murphy MP, Gowdy KM, Anderson EJ.
 J Am Heart Assoc. doi: 10.1161/JAHA.120.019877. PMID: 34219469

Scavenger Receptor BI Attenuates IL-7A-Dependent Neutrophilic Inflammation in Asthma.
Reece SW, Varikuti S, Kilburg-Basnyat B, Dunigan-Russell K, Hodge MX, Luo B, Madenspacher JH, Thomas SY, Tokarz DA, Tighe RM, Cook DN, Fessler MB, Gowdy KM. 
Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2020-0007OC. PMID: 33647226

2020

Cell Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.
Pal A, Gowdy KM, Oestreich KJ, Beck M, Shaikh SR.
Front Immunol. doi: 10.3389/fimmu.2020.01997. PMCID: PMC7438933.

Cholesterol 25-hydroxylase promotes efferocytosis and resolution in lung inflammation.
Madenspacher JH, Morrell ED, Gowdy KM, McDonald JG, Thompson BM, Muse G, Martinez J, Thomas S, Mikacenic C, Nick JA, Abraham E, Garantziotis S, Stapleton RD, Meacham JM, Thomassen MJ, Janssen WJ, Cook DN, Wurfel MM, Fessler MB. 
JCI Insight. doi: 10.1172/jci.insight.137189. PMCID: PMC7308063.
​
Estrogen receptor-a in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation.
Iñigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE.
Mol Metab. doi: 10.1016/j.molmet.2019.12.010. PMCID: PMC6994285.

TLR5 participates in the TLR4 complex and promotes MyD88-dependent signaling in environmental lung injury.
Hussain S, Johnson CG, Sciurba J, Meng X, Stober VP, Liu C, Cyphert-Daly JM, Bulek K, Qian W, Solis A, Sakamachi Y, Trempus CS, Aloor JJ, Gowdy KM, Foster WM, Hollingsworth JW, Tighe RM, Li X, Fessler MB, Garantziotis S.
Elife. doi: 10.7554/eLife.50458. PMCID: PMC7032926.

Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace.
Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB.
J Clin Invest. doi: 10.1172/JCI127144. PMCID: PMC6934223.

2019

Pulmonary Exposure to Magneli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function.
McDaniel DK, Ringel-Scaia VM, Morrison HA, Coutermarsh-Ott S, Council-Troche M, Angle JW, Perry JB, Davis G, Leng W, Minarchick V, Yang Y, Chen B, Reece SW, Brown DA, Cecere TE, Brown JM, Gowdy KM, Hochella MF Jr, Allen IC.
Front Immunol. doi: 10.3389/fimmu.2019.02714. PMCID: PMC6892980.

IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Grat-versus-host Disease.
Martinu T, McManigle WC, Kelly FL, Nelson ME, Sun J, Zhang HL, Kolls JK, Gowdy KM, Palmer SM.
Transplantation. doi: 10.1097/TP.0000000000002837. PMCID: PMC7550218.

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure.
Hodge MX, Reece SW, Madenspacher JH, Gowdy KM. 
J Vis Exp. doi: 10.3791/60109. PMCID: PMC7507829.

Correction: Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform.
Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH.
Biochem J. doi: 10.1042/BCJ-2019-0182_COR. Erratum for: Biochem J. PMID: 31519859.

Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatou Inflammation.
McPeek M, Malur A, Tokarz DA, Lertpiriyapong K, Gowdy KM, Murray G, Wingard CJ, Fessler MB, Barna BP, Thomassen MJ.
 Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2018-0365OC. PMCID: PMC6839925.

Sex Modifies Acute ozone-Mediated Airway Physiologic Responses.
Birukova A, Cyphert-Daly J, Cumming RI, Yu YR, Gowdy KM, Que LG, Tighe RM.
Toxicol Sci. doi: 10.1093/toxsci/kfz056. PMCID: PMC6542336.

Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a mulitplexed platform.
Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH.
Biochem J. doi: 10.1042/BCJ20190182. Erratum in: Biochem J. PMCID: PMC7071349.

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an association study.
​Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar D, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK, Hoyo C.
Epigenetics. doi: 10.1080/15592294.2019.1581594. PMCID: PMC6557549.Dietary Eicosapentaenoic Acid Improves Ozone-Induced Pulmonary Inflammation in C57BL/6 Mice.Lovins HB, Mehta A, Leuenberger LA, Yaeger MJ, Schott E, Hutton G, Manke J, Armstrong M, Reisdorph N, Tighe RM, Cochran SJ, Shaikh SR, Gowdy KM.J Nutr. 2025 Feb;155(2):465-475. doi: 10.1016/j.tjnut.2024.11.006. Epub 2024 Nov 12.PMID: 39536972

Influenza-Mediated Lung Infection Models.
McGee CE, Sample CJ, Kilburg-Basnyat B, Gabor KA, Fessler MB, Gowdy KM. 
Methods Mol Biol. doi: 10.1007/978-1-4939-9167-9_17. PMCID: PMC6675590.

Leucine-rich repeats and calponin homology containing 4 (Lrch4) regulates the innate immune response.
Aloor JJ, Azzam KM, Guardiola JJ, Gowdy KM, Madenspacher JH, Gabor KA, Mueller GA, Lin WC, Lowe JM, Gruzdev A, Henderson MW, Draper DW, Merrick BA, Fessler MB.
J Biol Chem. doi: 10.1074/jbc.RA118.004300. PMCID: PMC6369294.

​2018
​
Flow Cytometry for the Immunotoxicologist.
Espenschied ST, Tighe RM, Gowdy KM.
Methods Mol Biol. doi: 10.1007/978-1-4939-8549-4_12. PMID: 29882140.

Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation.
Tighe RM, Birukova A, Yaeger MJ, Reece SW, Gowdy KM.
Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2017-0357OC. PMCID: PMC6096344.

Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation.
Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, Armstrong ML, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM. 
Toxicol Sci. doi: 10.1093/toxsci/kfy040. PMCID: PMC5974791.

MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens.
Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN.
Mucosal Immunol. doi: 10.1038/mi.2017.84. PMCID: PMC5918466.

Ozone-Induced Vascular Contractility and Pulmonary Injury Are Differentially Impacted by Diets Enriched with Coconut, Fish Oil, and Olive Oil.
Snow SJ, Cheng WY, Henriquez A, Hodge M, Bass V, Nelson GM, Carswell G, Richards JE, Schladweiler MC, Ledbetter AD, Chorley B, Gowdy KM, Tong H, Kodavanti UP.
Toxicol Sci. doi: 10.1093/toxsci/kfy003. PMCID: PMC6659020.

Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction.
​McGee Hargrove M, Snow SJ, Luebke RW, Wood CE, Krug JD, Krantz QT, King C, Copeland CB, McCullough SD, Gowdy KM, Kodavanti UP, Gilmour MI, Gavett SH.
Environ Sci Technol. doi: 10.1021/acs.est.7b06534. PMCID: PMC6233996.
                                            
2017

​Effect of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice.
Henderson MW, Madenspacher JH, Whitehead GS, Thomas SY, Aloor JJ, Gowdy KM, Fessler MB.
Environ Health Perspect. doi: 10.1289/EHP1878. PMCID: PMC5915208.

lrgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
Azzam KM, Madenspacher JH, Cain DW, Lai L, Gowdy KM, Rai P, Janardhan K, Clayton N, Cunningham W, Jensen H, Patel PS, Kearney JF, Taylor GA, Fessler MB.
 JCI Insight. doi: 10.1172/jci.insight.91914. PMCID: PMC5621910.

B Cell Activity is Impaired in Human and Mouse Obesity and is Responsive to an Essential Fatty Acid upon Murine Influenza Infection.
Kosaraju R, Guesdon W, Crouch MJ, Teague HL, Sullivan EM, Karlsson EA, Schultz-Cherry S, Gowdy KM, Bridges LC, Reese LR, Neufer PD, Armstrong M, Reisdorph N, Milner JJ, Beck M, Shaikh SR.
J Immunol. doi: 10.4049/jimmunol.1601031. PMCID: PMC5482422.

2016

Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A Potential Role for Lipid Protein Adducts.
Speen AM, Kim HH, Bauer RN, Meyer M, Gowdy KM, Fessler MB, Duncan KE, Liu W, Porter NA, Jaspers I.
J Biol Chem. doi: 10.1074/jbc.M116.732362. PMCID: PMC5122785.

Role for phospholipid acyl chains and cholesterol in pulmonary infection and inflammation.
Shaikh SR, Fessler MB, Gowdy KM.
J Leukoc Biol. doi: 10.1189/jlb.4VMR0316-103R. PMCID: PMC5069085.

N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections.
Whelan J, Gowdy KM, Shaikh SR.
Eur J Pharmacol. doi: 10.1016/j.ejphar.2015.03.100. PMCID: PMC4662641.
​
Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling.
Thompson LC, Holland NA, Snyder RJ, Luo B, Becak DP, Odom JT, Harrison BS, Brown JM, Gowdy KM, Wingard CJ.
Am J Physiol Lung Cell Mol Physiol. doi: 10.1152/ajplung.00384.2014
PMCID: PMC4719050

2015

​Key role in scavenger receptor B-I in the integrative physiology of host defense pneumonia.
Gowdy KM, Madenspacher JH, Azzam KM, Gabor KA, Janardhan KS, Aloor JJ, Fessler MB.
Mucosal Immunol. DOI: 10.1038/mi.2014.88. PMCID: PMC4406784

Impaired CD8+ T-cell immunity after allogenic bone marrow transplantation leads to persistent and severe respiratory viral infection.
Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM.
Transpl Immunol.  doi: 10.1016/j.trim.2014.10.005. PMCID: PMC4277946

Trif-dependent induction of Th17 immunity by lung dendritic cells.
Hsia BJ, Whitehead GS, Thomas SY, Nakano K, Gowdy KM, Aloor JJ, Nakano H, Cook DN.
Mucosal Immunol. doi: 10.1038/mi.2014.56. PMCID: PMC4267961

2014

Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations.
Martinu T, Gowdy KM, Nugent JL, Sun J, Kinnier CV, Nelson ME, Lyes MA, Kelly FL, Foster WM, Gunn MD, Palmer SM.
Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2013-0451OC. PMCID: PMC4291544

2013
​
Emerging roles for cholesterol and lipoproteins in lung disease.
Gowdy KM, Fessler MB.
Pulm Pharmacol Ther. DOI: 10.1016/j.pupt.2012.06.002. PMCID: PMC3466369

Reply: To PMID 22921873.
Jaramillo R, Cohn RD, Crockett PW, Gowdy KM, Zeldin DC, Fessler MB.
J Allergy Clin Immunol. DOI: 10.1016/j.jaci.2013.04.004. PMID: 23642774

p53 Integrates host defense and cell fate during bacterial pneumonia.
Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB.
J Exp Med. DOI: 10.1084/jem.20121674. PMCID: PMC3646498

2012

Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.
Madenspacher JH, Azzam KM, Gong W, Gowdy KM, Vitek MP, Laskowitz DT, Remaley AT, Wang JM, Fessler MB.
J Biol Chem. doi: 10.1074/jbc.M112.377192. PMCID: PMC3527958

Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.
Zhu X, Westcott MM, Bi X, Liu M, Gowdy KM, Seo J, Cao Q, Gebre AK, Fessler MB, Hiltbold EM, Parks JS.
Circ Res. doi: 10.1161/CIRCRESAHA.112.269043. PMCID: PMC3494814

ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity.
Draper DW, Gowdy KM, Madenspacher JH, Wilson RH, Whitehead GS, Nakano H, Pandiri AR, Foley JF, Remaley AT, Cook DN, Fessler MB.
J Immunol. doi: 10.4049/jimmunol.1101605. PMCID: PMC3358405

Novel role for surfactant protein A in gastrointestinal graft-versus-hot disease.
Gowdy KM, Cardona DM, Nugent JL, Giamberardino C, Thomas JM, Mukherjee S, Martinu T, Foster WM, Plevy SE, Pastva AM, Wright JR, Palmer SM.
J Immunol. doi: 10.4049/jimmunol.1103558. PMCID: PMC3373011

Surfactant protein A modulates induction of regulatory T cells via TGF-B.
Mukherjee S, Giamberardino C, Thomas JM, Gowdy K, Pastva AM, Wright JR.
J Immunol.  DOI: 10.4049/jimmunol.1101775. PMCID: PMC3331948

Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis.
Gowdy KM, Nugent JL, Martinu T, Potts E, Snyder LD, Foster WM, Palmer SM.
Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2011-0131OC. PMCID: PMC3297167

2011

Innate immune activation potentiates alloimmune lung disease independent of chemokind (C-X-C motif) receptor 3.
Martinu T, Kinnier CV, Gowdy KM, Kelly FL, Snyder LD, Jiang D, Foster WM, Garantziotis S, Belperio JA, Noble PW, Palmer SM.
J Heart Lung Transplant. doi: 10.1016/j.healun.2011.01.711. PMCID: PMC3091946

Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant.
Kinnier CV, Martinu T, Gowdy KM, Nugent JL, Kelly FL, Palmer SM.
Transpl Immunol. doi: 10.1016/j.trim.2010.11.004. PMCID: PMC3015000

2010

Role of oxidative stress on diesel-enhanced influenza infection in mice.
Gowdy KM, Krantz QT, King C, Boykin E, Jaspers I, Linak WP, Gilmour MI.
Part Fibre Toxicol. doi: 10.1186/1743-8977-7-34. PMCID: PMC3001415

2008

Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust.
Gowdy K, Krantz QT, Daniels M, Linak WP, Jaspers I, Gilmour MI.
Toxicol Appl Pharmacol. doi: 10.1016/j.taap.2008.01.040. PMID: 18343473

2007

Diesel exhaust enhanced susceptibility to influenza infection is associated with decreased surfactant protein expression.
Ciencewicki J, Gowdy K, Krantz QT, Linak WP, Brighton L, Gilmour MI, Jaspers I.
Inhal Toxicol. doi: 10.1080/08958370701665426. PMID: 1798746